Please contact us for availability, pricing, and purchasing.

Description

Background: Microglia are central nervous system innate immune support cells that function remarkably like peripheral macrophages [1]. Microglia continually monitor neuronal function through direct cell-cell contacts and exert neuroprotective effects in response to stress [2]. By maintaining brain homeostasis, clearing cellular debris [3], pruning synapses [4], and eliminating protein aggregates [5], microglia play key roles in neurodevelopment [6], Alzheimer’s Disease [7], Parkinson’s Disease [8], ALS [9], traumatic brain injury [10], and many other central nervous system conditions

Vala Sciences, together with iXCells Biotechnologies, is proud to offer hiPSC-derived microglia for research and drug discovery. Suited for experiments in monoculture or in co-culture with hiPSC-derived neurons, our microglia will drive hiPSC-based neuroscience research forward.

Amount:  1 x 10^6 viably cells/tube of live culture in media

Species: Human

Brightfield image (20X) of Vala hiPSC-microglia in monoculture on Corning® Primaria™ surface.

Vala hiPSC-microglia (red) in co-culture with hiPSC-neurons (white) and hiPSC-astrocytes (green). Nucleus staining (Hoescht) in blue.

References

1. Ginhoux F and Prinz M. Origin of Microglia: Current Concepts and Past Controversies. Cold Spring Harbor Perspectives in Biology. Aug 2015; 7(8):a020537.
2. Cserép C, Pósfai B, Lénárt N, et al. Microglia monitor and protect neuronal function via specialized somatic purinergic junctions. Science.  Jan 2020; 367(6477):528-537.
3. Sierra A, Encinas JM, Deudero JJP, et al. Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis. Cell Stem Cell. Oct 2010; 7(4):483-495.
4. Paolicelli RC, Bolasco G, Pagani F, et al. Synaptic Pruning by Microglia Is Necessary for Normal Brain Development. Science. Sep 2011; 333(6048):1456-1458.
5. Sierra A, Abiega O, Shahraz A, and Neumann H. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Frontiers in Cellular Neuroscience. Jan 2013; 7:6.
6. Lenz KM and Nelson LH. Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function. Frontiers in Immunology. Apr 2018; 9:698.
7. Paasila PJ, Aramideh JA, Sutherland GT, and Graeber MB. Synapses, Microglia, and Lipids in Alzheimer’s Disease. Frontiers in Neuroscience. Jan 2022; 15:778822.
8. Choi I, Zhang Y, Seegobin SP, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications. Dec 2020; 11(1):1386.
9. Clarke BE and Patani R. The microglial component of amyotrophic lateral sclerosis. Brain. Dec 2020; 143(12):3526-3539.
10. Xu L, Wang J, Ding Y, Wang L, and Zhu Y. Current Knowledge of Microglia in Traumatic Spinal Cord Injury. Frontiers in Neurology. Jan 2022; 12:796704.

Please use this form to email Vala, or call today at (888) 742-VALA (8252).