hiPSC-Derived Microglia (iXCells Biotechnologies Cat. CXPR-25)
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Background: Microglia are central nervous system innate immune support cells that function remarkably like peripheral macrophages . Microglia continually monitor neuronal function through direct cell-cell contacts and exert neuroprotective effects in response to stress . By maintaining brain homeostasis, clearing cellular debris , pruning synapses , and eliminating protein aggregates , microglia play key roles in neurodevelopment , Alzheimer’s Disease , Parkinson’s Disease , ALS , traumatic brain injury , and many other central nervous system conditions
Vala Sciences, together with iXCells Biotechnologies, is proud to offer hiPSC-derived microglia for research and drug discovery. Suited for experiments in monoculture or in co-culture with hiPSC-derived neurons, our microglia will drive hiPSC-based neuroscience research forward.
Amount: 1 x 10^6 viably cells/tube of live culture in media
Brightfield image (20X) of Vala hiPSC-microglia in monoculture on Corning® Primaria™ surface.
Vala hiPSC-microglia (red) in co-culture with hiPSC-neurons (white) and hiPSC-astrocytes (green). Nucleus staining (Hoescht) in blue.
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- Sierra A, Encinas JM, Deudero JJP, et al. Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis. Cell Stem Cell. Oct 2010; 7(4):483-495.
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- Paasila PJ, Aramideh JA, Sutherland GT, and Graeber MB. Synapses, Microglia, and Lipids in Alzheimer’s Disease. Frontiers in Neuroscience. Jan 2022; 15:778822.
- Choi I, Zhang Y, Seegobin SP, et al. Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications. Dec 2020; 11(1):1386.
- Clarke BE and Patani R. The microglial component of amyotrophic lateral sclerosis. Brain. Dec 2020; 143(12):3526-3539.
- Xu L, Wang J, Ding Y, Wang L, and Zhu Y. Current Knowledge of Microglia in Traumatic Spinal Cord Injury. Frontiers in Neurology. Jan 2022; 12:796704.
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